TENT4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905870Biological processpositive regulation of 3'-UTR-mediated mRNA stabilization
GO_0007062Biological processsister chromatid cohesion
GO_0006397Biological processmRNA processing
GO_0071076Biological processRNA 3' uridylation
GO_0006302Biological processdouble-strand break repair
GO_0060212Biological processnegative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0007076Biological processmitotic chromosome condensation
GO_0043634Biological processpolyadenylation-dependent ncRNA catabolic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0031123Biological processRNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0031499Cellular componentTRAMP complex
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0070568Molecular functionguanylyltransferase activity
GO_1990817Molecular functionpoly(A) RNA polymerase activity
GO_0043221Molecular functionSMC family protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTENT4A
Protein nameTerminal nucleotidyltransferase 4A
Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)
SynonymsTRF4
POLS
PAPD7
DescriptionFUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation . Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation . .

AccessionsA0A9H4DBI9
Q5XG87
ENST00000631941.2
ENST00000515721.1
ENST00000230859.8 [Q5XG87-1]
D6RJD0