TDP1 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	31% ± 9%	Explore
glutamatergic neuron	3 studies	38% ± 7%	Explore

Name	Number of supported studies	Average coverage
brain	5 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	714.22	459 / 459	100%	14.73	1118 / 1118
intestine	100%	599.23	966 / 966	100%	11.47	527 / 527
ovary	100%	630.28	180 / 180	100%	11.99	430 / 430
stomach	100%	478.74	359 / 359	100%	10.59	286 / 286
uterus	100%	551.65	170 / 170	100%	14.28	459 / 459
esophagus	100%	576.00	1443 / 1445	100%	10.65	183 / 183
bladder	100%	577.24	21 / 21	100%	12.46	502 / 504
prostate	100%	617.31	245 / 245	100%	9.01	500 / 502
brain	99%	567.24	2622 / 2642	100%	7.72	705 / 705
skin	100%	963.80	1809 / 1809	99%	9.99	468 / 472
lung	100%	505.42	576 / 578	99%	10.19	1142 / 1155
kidney	100%	600.33	89 / 89	98%	7.05	883 / 901
pancreas	99%	395.68	325 / 328	99%	7.78	176 / 178
thymus	100%	395.39	652 / 653	95%	6.56	572 / 605
adrenal gland	100%	523.58	257 / 258	90%	4.59	206 / 230
liver	95%	267.25	215 / 226	89%	4.42	363 / 406
adipose	100%	560.77	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	22.80	29 / 29
spleen	100%	1115.11	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	13.49	45 / 45
ureter	0%	0	0 / 0	100%	9.74	1 / 1
blood vessel	100%	390.50	1331 / 1335	0%	0	0 / 0
peripheral blood	97%	1193.95	904 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	95%	6.26	76 / 80
heart	75%	158.57	650 / 861	0%	0	0 / 0
muscle	58%	104.15	462 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006281	Biological process	DNA repair
GO_0000012	Biological process	single strand break repair
GO_0006302	Biological process	double-strand break repair
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003690	Molecular function	double-stranded DNA binding
GO_0017005	Molecular function	3'-tyrosyl-DNA phosphodiesterase activity
GO_0004527	Molecular function	exonuclease activity
GO_0005515	Molecular function	protein binding
GO_0003697	Molecular function	single-stranded DNA binding

Gene name	TDP1
Protein name	Tyrosyl-DNA phosphodiesterase 1 Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 protein (Tyrosyl-DNA phosphodiesterase 1) TDP1 protein
Synonyms
Description	FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. .
Accessions	G3V2F4 ENST00000556867.1 ENST00000556063.1 ENST00000553527.1 ENST00000556498.1 G3V2U6 G3V5F9 G3V554 Q32Q25 ENST00000555880.5 ENST00000555178.5 ENST00000554976.5 Q9BRS7 ENST00000393454.6 [Q9NUW8-1] Q9NUW8 G3V5H9 G3V3Q0 ENST00000335725.9 [Q9NUW8-1] ENST00000393452.7 ENST00000553617.5 ENST00000545686.6 H0YJ44 ENST00000553989.1 G3V4W8 G3V2J6 G3V5B8 E7EPD8 H0YJL7 ENST00000557782.1 ENST00000554180.5

TDP1 report