I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 77% ± 8% | |
| fibroblast | 4 studies | 25% ± 7% | |
| endothelial cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 77% ± 8% | |
| fibroblast | 4 studies | 25% ± 7% | |
| endothelial cell | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of TDO2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 18998.41 | 226 / 226 | 95% | 96.05 | 386 / 406 |
| lung | 94% | 279.70 | 545 / 578 | 84% | 4.20 | 972 / 1155 |
| intestine | 81% | 160.76 | 786 / 966 | 70% | 4.12 | 369 / 527 |
| esophagus | 37% | 21.25 | 536 / 1445 | 78% | 3.50 | 142 / 183 |
| adrenal gland | 94% | 123.16 | 243 / 258 | 19% | 1.37 | 44 / 230 |
| pancreas | 30% | 13.10 | 99 / 328 | 79% | 3.98 | 141 / 178 |
| bladder | 24% | 17.14 | 5 / 21 | 74% | 3.35 | 375 / 504 |
| spleen | 95% | 162.02 | 228 / 241 | 0% | 0 | 0 / 0 |
| stomach | 23% | 7.63 | 81 / 359 | 66% | 3.60 | 190 / 286 |
| ovary | 18% | 4.67 | 33 / 180 | 70% | 4.82 | 299 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 4.19 | 25 / 29 |
| kidney | 52% | 33.71 | 46 / 89 | 32% | 1.23 | 291 / 901 |
| breast | 16% | 5.57 | 73 / 459 | 67% | 3.23 | 749 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 2.68 | 33 / 45 |
| brain | 45% | 33.07 | 1194 / 2642 | 27% | 1.17 | 192 / 705 |
| skin | 9% | 3.22 | 157 / 1809 | 60% | 4.60 | 281 / 472 |
| uterus | 15% | 6.04 | 26 / 170 | 46% | 2.69 | 213 / 459 |
| prostate | 20% | 9.60 | 50 / 245 | 22% | 7.07 | 110 / 502 |
| thymus | 15% | 7.05 | 101 / 653 | 26% | 0.89 | 157 / 605 |
| adipose | 22% | 16.32 | 264 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 15% | 13.97 | 198 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 13% | 16.56 | 125 / 929 | 0% | 0 | 0 / 0 |
| muscle | 6% | 3.23 | 47 / 803 | 0% | 0 | 0 / 0 |
| heart | 2% | 0.92 | 16 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019441 | Biological process | tryptophan catabolic process to kynurenine |
| GO_0019442 | Biological process | tryptophan catabolic process to acetyl-CoA |
| GO_1904842 | Biological process | response to nitroglycerin |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0005829 | Cellular component | cytosol |
| GO_0016597 | Molecular function | amino acid binding |
| GO_0019825 | Molecular function | oxygen binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004833 | Molecular function | tryptophan 2,3-dioxygenase activity |
| Gene name | TDO2 |
| Protein name | Tryptophan 2,3-dioxygenase Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) |
| Synonyms | TDO |
| Description | FUNCTION: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. . |
| Accessions | ENST00000574434.5 D6RB68 P48775 ENST00000573403.1 ENST00000506072.5 ENST00000573644.5 ENST00000507590.5 D6RA50 ENST00000536354.3 |
