TBC1D7 | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	28% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	681.49	1809 / 1809	100%	49.70	472 / 472
ovary	100%	386.43	180 / 180	100%	8.98	429 / 430
stomach	100%	381.19	359 / 359	100%	6.73	285 / 286
prostate	100%	664.99	245 / 245	100%	6.69	500 / 502
uterus	100%	463.69	170 / 170	100%	9.44	457 / 459
breast	100%	558.44	459 / 459	100%	8.22	1113 / 1118
bladder	100%	477.38	21 / 21	99%	8.53	501 / 504
lung	100%	607.95	577 / 578	100%	8.09	1150 / 1155
liver	100%	455.94	226 / 226	99%	5.93	403 / 406
intestine	100%	539.53	966 / 966	99%	7.05	522 / 527
brain	100%	580.19	2630 / 2642	99%	6.52	701 / 705
esophagus	100%	521.17	1445 / 1445	99%	5.97	181 / 183
thymus	100%	443.55	653 / 653	98%	4.29	591 / 605
pancreas	99%	291.35	326 / 328	97%	5.02	173 / 178
kidney	100%	883.17	89 / 89	92%	5.21	833 / 901
adrenal gland	100%	557.67	258 / 258	91%	3.76	209 / 230
adipose	100%	475.33	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	42.79	80 / 80
lymph node	0%	0	0 / 0	100%	8.25	29 / 29
spleen	100%	617.60	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	7.55	45 / 45
ureter	0%	0	0 / 0	100%	8.46	1 / 1
blood vessel	100%	521.28	1332 / 1335	0%	0	0 / 0
peripheral blood	100%	869.04	926 / 929	0%	0	0 / 0
muscle	99%	449.16	798 / 803	0%	0	0 / 0
heart	99%	872.91	850 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0032007	Biological process	negative regulation of TOR signaling
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_1902018	Biological process	negative regulation of cilium assembly
GO_0009267	Biological process	cellular response to starvation
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0070848	Biological process	response to growth factor
GO_0090630	Biological process	activation of GTPase activity
GO_1904262	Biological process	negative regulation of TORC1 signaling
GO_0033596	Cellular component	TSC1-TSC2 complex
GO_0036064	Cellular component	ciliary basal body
GO_0005829	Cellular component	cytosol
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005765	Cellular component	lysosomal membrane
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0005096	Molecular function	GTPase activator activity

Gene name	TBC1D7
Protein name	TBC1 domain family member 7 TBC1 domain family member 7 (Cell migration-inducing protein 23)
Synonyms	TBC7 HSPC239
Description	FUNCTION: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 . In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling . The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 . .
Accessions	ENST00000416436.5 U3KPY5 ENST00000607230.1 ENST00000452989.5 Q9P0N9 Q5SZL8 ENST00000607658.5 ENST00000450347.5 ENST00000420456.5 Q5SZM2 ENST00000343141.8 [Q9P0N9-4] U3KQ23 ENST00000606370.5 ENST00000606541.5 Q5SZL4 ENST00000379307.6 [Q9P0N9-2] ENST00000422136.5 ENST00000379300.8 [Q9P0N9-1] ENST00000356436.8 [Q9P0N9-1] ENST00000446018.5 ENST00000421203.6 ENST00000606214.5 [Q9P0N9-1] U3KPS8 ENST00000379291.5 U3KQQ0 ENST00000606530.1 B4DK47 Q5SZL6 U3KQD8 Q5SZL3 Q5SZM1 Q5SZL5 ENST00000428109.5

TBC1D7 report