TBC1D21 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TBC1D21 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBC1D21 at tissue level.

III. Associated gene sets

GO_0007288Biological processsperm axoneme assembly
GO_0007283Biological processspermatogenesis
GO_0030317Biological processflagellated sperm motility
GO_1902017Biological processregulation of cilium assembly
GO_0090630Biological processactivation of GTPase activity
GO_0120317Biological processsperm mitochondrial sheath assembly
GO_0097225Cellular componentsperm midpiece
GO_0070062Cellular componentextracellular exosome
GO_0005856Cellular componentcytoskeleton
GO_0001669Cellular componentacrosomal vesicle
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameTBC1D21
Protein nameTBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)
Alternative protein TBC1D21
TBC1 domain family member 21
SynonymsMGCRABGAP
DescriptionFUNCTION: Acts as a GTPase-activating protein for Rab family protein(s) . Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (By similarity). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (By similarity). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (By similarity). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity . .

AccessionsENST00000300504.7 [Q8IYX1-1]
Q8IYX1
L0R6Q7
ENST00000562056.1
ENST00000535547.6 [Q8IYX1-2]
H3BTA9