TBC1D2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902017Biological processregulation of cilium assembly
GO_0043547Biological processpositive regulation of GTPase activity
GO_0090630Biological processactivation of GTPase activity
GO_0030054Cellular componentcell junction
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0070161Cellular componentanchoring junction
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0045296Molecular functioncadherin binding
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameTBC1D2
Protein nameTBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)
SynonymsPP8997
PARIS1
TBC1D2A
DescriptionFUNCTION: Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. .

AccessionsENST00000375063.5 [Q9BYX2-6]
ENST00000375064.5 [Q9BYX2-3]
Q9BYX2
ENST00000375066.6 [Q9BYX2-2]
ENST00000465784.7 [Q9BYX2-1]
ENST00000342112.9 [Q9BYX2-4]