TARBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030488Biological processtRNA methylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0016423Molecular functiontRNA (guanine) methyltransferase activity

IV. Literature review

[source]
Gene nameTARBP1
Protein nameProbable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)
SynonymsTRM3
TRP185
DescriptionFUNCTION: Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. .; FUNCTION: (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II . Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA . .

AccessionsQ13395
ENST00000040877.2