TAFAZZIN report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TAFAZZIN at tissue level.

III. Associated gene sets

GO_0007519Biological processskeletal muscle tissue development
GO_0030097Biological processhemopoiesis
GO_0048137Biological processspermatocyte division
GO_0007507Biological processheart development
GO_0007007Biological processinner mitochondrial membrane organization
GO_0006936Biological processmuscle contraction
GO_0060048Biological processcardiac muscle contraction
GO_0003007Biological processheart morphogenesis
GO_0007005Biological processmitochondrion organization
GO_0042407Biological processcristae formation
GO_0035965Biological processcardiolipin acyl-chain remodeling
GO_0032048Biological processcardiolipin metabolic process
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_0032049Biological processcardiolipin biosynthetic process
GO_0048738Biological processcardiac muscle tissue development
GO_0042775Biological processmitochondrial ATP synthesis coupled electron transport
GO_0000423Biological processmitophagy
GO_1900210Biological processpositive regulation of cardiolipin metabolic process
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0008374Molecular functionO-acyltransferase activity
GO_0047184Molecular function1-acylglycerophosphocholine O-acyltransferase activity

IV. Literature review

[source]
Gene nameTAFAZZIN
Protein nameTafazzin family protein
Tafazzin (Taz) (EC 2.3.1.-) (Protein G4.5)
Tafazzin, phospholipid-lysophospholipid transacylase
SynonymsTAZ
G4.5
EFE2
DescriptionFUNCTION: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function . Its role in cellular physiology is to improve mitochondrial performance . CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy . Required to ensure progression of spermatocytes through meiosis (By similarity). Exon 7 of human tafazzin is essential for catalysis . .; FUNCTION: [Isoform 1]: Catalyzes the transacylation between lysophosphatidate (such as 1-acyl-sn-glycero-3-phosphate) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)) . Contributes to cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL) remodeling . .; FUNCTION: [Isoform 3]: Catalyzes the transacylation between lysophospholipids and phospholipids, and plays a fundamental role in cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL) metabolism and remodeling. .; FUNCTION: [Isoform 5]: Catalytically inactive. .; FUNCTION: [Isoform 7]: Catalytically inactive. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

FUNCTION: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis. .

AccessionsENST00000616020.5
ENST00000620808.4
ENST00000617701.5
A0A494C0V5
A0A0S2Z4E6
ENST00000651139.1
A0A0S2Z4F4
ENST00000652682.1
ENST00000652358.1
F6Y2X3
ENST00000652354.1
A0A494C0D2
ENST00000615986.4
A0A494C1C6
ENST00000369776.8
A0A0S2Z4K9
ENST00000601016.6 [Q16635-1]
H7C2I9
A0A494C0C5
Q16635
A6XNE1
ENST00000439735.2
ENST00000475699.6
ENST00000612460.5 [Q16635-3]
C9J699
A0A087WWD5
Q2VF39
ENST00000612012.5 [Q16635-5]
ENST00000613002.4 [Q16635-7]
A0A0S2Z4K0
A0A494C004
ENST00000479875.1
ENST00000652390.1
ENST00000652644.1
A0A494C1B0
ENST00000426231.5
A0A499FJ53
A0A494C141