SYNE4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SYNE4 at tissue level.

III. Associated gene sets

GO_0045198Biological processestablishment of epithelial cell apical/basal polarity
GO_0005640Cellular componentnuclear outer membrane
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSYNE4
Protein nameNesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)
Spectrin repeat containing nuclear envelope family member 4
SynonymsC19orf46
DescriptionFUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). .

AccessionsH0Y9Z1
ENST00000397428.8
ENST00000490730.1
ENST00000340477.9 [Q8N205-2]
D6RAE3
Q8N205
H9KVA3
ENST00000503121.5
ENST00000324444.9 [Q8N205-1]