SVEP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008544Biological processepidermis development
GO_0007160Biological processcell-matrix adhesion
GO_0045959Biological processnegative regulation of complement activation, classical pathway
GO_0003017Biological processlymph circulation
GO_0120193Biological processtight junction organization
GO_0048014Biological processTie signaling pathway
GO_0036303Biological processlymph vessel morphogenesis
GO_0045906Biological processnegative regulation of vasoconstriction
GO_0010467Biological processgene expression
GO_0010572Biological processpositive regulation of platelet activation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0005178Molecular functionintegrin binding
GO_0098640Molecular functionintegrin binding involved in cell-matrix adhesion
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSVEP1
Protein nameAlternative protein SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)
SynonymsSELOB
CCP22
C9orf13
DescriptionFUNCTION: Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (By similarity). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction . Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling . Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion . May play a role in initial cell attachment of stromal osteogenic cells (By similarity). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (By similarity). .

AccessionsQ4LDE5
L8EBF2
ENST00000374469.6 [Q4LDE5-1]
ENST00000374461.1 [Q4LDE5-2]