SV2C | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SV2C at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	92%	3004.64	2441 / 2642	35%	1.46	250 / 705
prostate	63%	90.94	154 / 245	61%	1.46	308 / 502
stomach	94%	222.86	337 / 359	6%	0.13	17 / 286
ovary	56%	148.95	101 / 180	26%	1.18	113 / 430
adrenal gland	21%	59.04	55 / 258	52%	7.17	119 / 230
intestine	47%	65.29	455 / 966	4%	0.09	23 / 527
esophagus	28%	42.71	410 / 1445	2%	0.02	3 / 183
bladder	19%	28.05	4 / 21	6%	0.12	28 / 504
breast	22%	22.48	101 / 459	2%	0.03	18 / 1118
skin	18%	18.20	317 / 1809	3%	0.13	15 / 472
spleen	12%	10.60	28 / 241	0%	0	0 / 0
lung	9%	8.90	53 / 578	2%	0.03	19 / 1155
uterus	5%	8.24	8 / 170	4%	0.14	20 / 459
adipose	8%	7.60	95 / 1204	0%	0	0 / 0
heart	6%	7.71	55 / 861	0%	0	0 / 0
pancreas	3%	2.45	9 / 328	3%	0.05	5 / 178
tonsil	0%	0	0 / 0	4%	0.05	2 / 45
kidney	2%	2.94	2 / 89	1%	0.03	7 / 901
blood vessel	2%	2.38	26 / 1335	0%	0	0 / 0
thymus	1%	1.21	8 / 653	0%	0.02	2 / 605
liver	0%	0.45	1 / 226	1%	0.03	4 / 406
eye	0%	0	0 / 0	1%	0.10	1 / 80
peripheral blood	1%	1.25	6 / 929	0%	0	0 / 0
muscle	0%	0.70	4 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007268	Biological process	chemical synaptic transmission
GO_2000300	Biological process	regulation of synaptic vesicle exocytosis
GO_0055085	Biological process	transmembrane transport
GO_0006836	Biological process	neurotransmitter transport
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0008021	Cellular component	synaptic vesicle
GO_0098691	Cellular component	dopaminergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0005515	Molecular function	protein binding
GO_0022857	Molecular function	transmembrane transporter activity

Gene name	SV2C
Protein name	Synaptic vesicle glycoprotein 2C
Synonyms	KIAA1054
Description	FUNCTION: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. .; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 . Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A . Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction . .; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans. .
Accessions	Q496J9 ENST00000502798.7 B3KT41 ENST00000322285.7

SV2C report