SUMO4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SUMO4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SUMO4 at tissue level.

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_1900180Biological processregulation of protein localization to nucleus
GO_0034599Biological processcellular response to oxidative stress
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0043388Biological processpositive regulation of DNA binding
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043392Biological processnegative regulation of DNA binding
GO_0106068Cellular componentSUMO ligase complex
GO_0005634Cellular componentnucleus
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0031386Molecular functionprotein tag activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSUMO4
Protein nameSmall ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
SynonymsSMT3H4
DescriptionFUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. .

AccessionsQ6EEV6
ENST00000326669.6