Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 5 studies | 58% ± 8% | |
| basal cell | 3 studies | 22% ± 4% | |
| fibroblast | 3 studies | 56% ± 26% | |
| progenitor cell | 3 studies | 38% ± 15% | |
| connective tissue cell | 3 studies | 39% ± 27% | |
| enterocyte | 3 studies | 25% ± 7% | |
| epithelial cell | 3 studies | 32% ± 16% | |
| hepatocyte | 3 studies | 46% ± 29% |
Insufficient scRNA-seq data for expression of SULT1E1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 76% | 1229.96 | 171 / 226 | 53% | 4.40 | 215 / 406 |
| adrenal gland | 99% | 1292.90 | 255 / 258 | 8% | 0.21 | 18 / 230 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.61 | 1 / 1 |
| lung | 62% | 228.37 | 359 / 578 | 27% | 2.88 | 310 / 1155 |
| skin | 82% | 1321.26 | 1476 / 1809 | 3% | 1.06 | 14 / 472 |
| stomach | 35% | 130.13 | 127 / 359 | 36% | 4.56 | 102 / 286 |
| esophagus | 9% | 21.45 | 124 / 1445 | 52% | 6.14 | 95 / 183 |
| bladder | 29% | 50.95 | 6 / 21 | 30% | 5.96 | 150 / 504 |
| pancreas | 0% | 0.49 | 1 / 328 | 56% | 4.75 | 100 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 12.97 | 22 / 45 |
| uterus | 6% | 53.18 | 10 / 170 | 36% | 4.54 | 163 / 459 |
| intestine | 16% | 165.35 | 156 / 966 | 22% | 2.17 | 114 / 527 |
| prostate | 15% | 49.20 | 37 / 245 | 2% | 0.03 | 9 / 502 |
| ovary | 1% | 1.47 | 2 / 180 | 10% | 0.60 | 45 / 430 |
| breast | 3% | 5.65 | 15 / 459 | 6% | 0.48 | 64 / 1118 |
| kidney | 6% | 9.37 | 5 / 89 | 3% | 0.10 | 29 / 901 |
| blood vessel | 7% | 22.12 | 92 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.65 | 2 / 653 | 1% | 0.02 | 6 / 605 |
| brain | 0% | 0.14 | 3 / 2642 | 1% | 0.04 | 4 / 705 |
| adipose | 0% | 4.98 | 5 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 0% | 1.20 | 1 / 241 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.59 | 3 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050427 | Biological process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| GO_0006068 | Biological process | ethanol catabolic process |
| GO_0051923 | Biological process | sulfation |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0045600 | Biological process | positive regulation of fat cell differentiation |
| GO_0006711 | Biological process | estrogen catabolic process |
| GO_0008210 | Biological process | estrogen metabolic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0047894 | Molecular function | flavonol 3-sulfotransferase activity |
| GO_0004304 | Molecular function | estrone sulfotransferase activity |
| GO_0050294 | Molecular function | steroid sulfotransferase activity |
| GO_0008146 | Molecular function | sulfotransferase activity |
| GO_0004062 | Molecular function | aryl sulfotransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005496 | Molecular function | steroid binding |
| Gene name | SULT1E1 |
| Protein name | Sulfotransferase (EC 2.8.2.-) Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring) |
| Synonyms | STE hCG_38316 |
| Description | FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone . Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency . Does not sulfonate cortisol, testosterone and dopamine . May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. . |
| Accessions | ENST00000226444.4 P49888 Q53X91 |
