SULT1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006584Biological processcatecholamine metabolic process
GO_0050427Biological process3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO_0009812Biological processflavonoid metabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0006068Biological processethanol catabolic process
GO_0051923Biological processsulfation
GO_0009308Biological processamine metabolic process
GO_0008210Biological processestrogen metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0050656Molecular function3'-phosphoadenosine 5'-phosphosulfate binding
GO_0050294Molecular functionsteroid sulfotransferase activity
GO_0008146Molecular functionsulfotransferase activity
GO_0004062Molecular functionaryl sulfotransferase activity
GO_0005515Molecular functionprotein binding
GO_0047894Molecular functionflavonol 3-sulfotransferase activity

IV. Literature review

[source]
Gene nameSULT1A1
Protein nameSulfotransferase (EC 2.8.2.-)
Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)
SynonymsSTP1
STP
OK/SW-cl.88
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin . Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis . May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. .

AccessionsENST00000569554.5 [P50225-1]
ENST00000567512.1
ENST00000314752.12 [P50225-1]
H3BRY5
P50225
ENST00000566189.5
H3BQX5