Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 20 studies | 31% ± 12% | |
non-classical monocyte | 17 studies | 24% ± 10% | |
ciliated cell | 8 studies | 20% ± 7% | |
type I pneumocyte | 7 studies | 28% ± 9% | |
monocyte | 6 studies | 24% ± 3% | |
enterocyte | 6 studies | 41% ± 17% | |
fibroblast | 6 studies | 27% ± 15% | |
epithelial cell | 6 studies | 27% ± 11% | |
endothelial cell | 4 studies | 23% ± 3% | |
macrophage | 4 studies | 23% ± 5% | |
oligodendrocyte precursor cell | 4 studies | 24% ± 4% | |
glutamatergic neuron | 3 studies | 49% ± 23% | |
capillary endothelial cell | 3 studies | 18% ± 2% | |
astrocyte | 3 studies | 27% ± 4% | |
hepatocyte | 3 studies | 30% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 5816.43 | 225 / 226 | 98% | 18.00 | 396 / 406 |
thymus | 100% | 2925.67 | 653 / 653 | 94% | 9.73 | 571 / 605 |
kidney | 98% | 1582.65 | 87 / 89 | 87% | 6.50 | 782 / 901 |
adrenal gland | 100% | 4838.89 | 258 / 258 | 84% | 7.55 | 193 / 230 |
breast | 96% | 1165.81 | 441 / 459 | 85% | 6.28 | 953 / 1118 |
lung | 100% | 2421.19 | 577 / 578 | 75% | 4.54 | 871 / 1155 |
pancreas | 97% | 786.51 | 318 / 328 | 76% | 3.19 | 135 / 178 |
ovary | 88% | 632.59 | 159 / 180 | 82% | 3.81 | 352 / 430 |
prostate | 93% | 829.59 | 229 / 245 | 69% | 2.33 | 344 / 502 |
stomach | 95% | 1022.06 | 340 / 359 | 67% | 3.58 | 192 / 286 |
intestine | 83% | 1934.20 | 797 / 966 | 71% | 3.74 | 376 / 527 |
brain | 99% | 1783.45 | 2622 / 2642 | 50% | 2.05 | 355 / 705 |
bladder | 76% | 660.29 | 16 / 21 | 65% | 3.94 | 326 / 504 |
uterus | 75% | 470.16 | 127 / 170 | 56% | 2.79 | 258 / 459 |
esophagus | 70% | 425.60 | 1018 / 1445 | 48% | 2.04 | 88 / 183 |
spleen | 100% | 3501.61 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.17 | 1 / 1 |
adipose | 94% | 1140.54 | 1132 / 1204 | 0% | 0 | 0 / 0 |
heart | 86% | 765.61 | 739 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 80% | 2301.12 | 745 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 6.15 | 57 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 2.97 | 19 / 29 |
skin | 18% | 80.88 | 321 / 1809 | 34% | 2.01 | 160 / 472 |
muscle | 43% | 207.69 | 342 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 41% | 279.81 | 544 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 27% | 0.91 | 12 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006584 | Biological process | catecholamine metabolic process |
GO_0050427 | Biological process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
GO_0009812 | Biological process | flavonoid metabolic process |
GO_0006805 | Biological process | xenobiotic metabolic process |
GO_0006068 | Biological process | ethanol catabolic process |
GO_0051923 | Biological process | sulfation |
GO_0009308 | Biological process | amine metabolic process |
GO_0008210 | Biological process | estrogen metabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0050656 | Molecular function | 3'-phosphoadenosine 5'-phosphosulfate binding |
GO_0050294 | Molecular function | steroid sulfotransferase activity |
GO_0008146 | Molecular function | sulfotransferase activity |
GO_0004062 | Molecular function | aryl sulfotransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0047894 | Molecular function | flavonol 3-sulfotransferase activity |
Gene name | SULT1A1 |
Protein name | Sulfotransferase (EC 2.8.2.-) Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) |
Synonyms | STP1 STP OK/SW-cl.88 |
Description | FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin . Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis . May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. . |
Accessions | ENST00000569554.5 [P50225-1] ENST00000567512.1 ENST00000314752.12 [P50225-1] H3BRY5 P50225 ENST00000566189.5 H3BQX5 |