STXBP5L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0006887Biological processexocytosis
GO_0006893Biological processGolgi to plasma membrane transport
GO_0005737Cellular componentcytoplasm
GO_0005886Cellular componentplasma membrane
GO_0031201Cellular componentSNARE complex
GO_0045159Molecular functionmyosin II binding
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameSTXBP5L
Protein nameSyntaxin binding protein 5L
Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2)
SynonymsKIAA1006
LLGL4
DescriptionFUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth . .

AccessionsENST00000492541.5
C9K0E4
C9JQS3
ENST00000497029.5
ENST00000471454.6
ENST00000707001.1 [Q9Y2K9-1]
E9PFI2
C9JPK3
ENST00000472879.5
ENST00000471262.1
C9JUZ7
Q9Y2K9
ENST00000273666.10 [Q9Y2K9-1]
C9JCY1
ENST00000461772.5 [Q9Y2K9-2]
ENST00000495504.5