STX1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0050796Biological processregulation of insulin secretion
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0017156Biological processcalcium-ion regulated exocytosis
GO_0006886Biological processintracellular protein transport
GO_0016079Biological processsynaptic vesicle exocytosis
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_0032940Biological processsecretion by cell
GO_0006887Biological processexocytosis
GO_0010807Biological processregulation of synaptic vesicle priming
GO_0010701Biological processpositive regulation of norepinephrine secretion
GO_0048278Biological processvesicle docking
GO_0045956Biological processpositive regulation of calcium ion-dependent exocytosis
GO_0033605Biological processpositive regulation of catecholamine secretion
GO_0001956Biological processpositive regulation of neurotransmitter secretion
GO_0030073Biological processinsulin secretion
GO_0031629Biological processsynaptic vesicle fusion to presynaptic active zone membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0048787Cellular componentpresynaptic active zone membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0070044Cellular componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
GO_0030424Cellular componentaxon
GO_0031965Cellular componentnuclear membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0031201Cellular componentSNARE complex
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0000149Molecular functionSNARE binding
GO_0019855Molecular functioncalcium channel inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0005484Molecular functionSNAP receptor activity
GO_0019869Molecular functionchloride channel inhibitor activity

IV. Literature review

[source]
Gene nameSTX1A
Protein nameSyntaxin-1A (Neuron-specific antigen HPC-1)
Syntaxin-1A
SynonymsSTX1
hCG_96107
DescriptionFUNCTION: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis . Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm . Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). .

AccessionsX5D7S1
Q75ME0
Q16623
A0A0C4DFZ1
ENST00000395155.3
ENST00000395156.7 [Q16623-3]
ENST00000222812.8 [Q16623-1]
ENST00000395154.7
A8MZ54