Insufficient scRNA-seq data for expression of STRIT1 at single-cell level.
Insufficient scRNA-seq data for expression of STRIT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
muscle | 100% | 33474.19 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.41 | 1 / 1 |
kidney | 67% | 79.54 | 60 / 89 | 14% | 0.42 | 127 / 901 |
heart | 43% | 41.17 | 374 / 861 | 0% | 0 | 0 / 0 |
prostate | 21% | 120.68 | 52 / 245 | 17% | 4.14 | 87 / 502 |
brain | 29% | 126.93 | 768 / 2642 | 0% | 0.02 | 2 / 705 |
adipose | 25% | 13.94 | 302 / 1204 | 0% | 0 | 0 / 0 |
lung | 20% | 5.23 | 118 / 578 | 3% | 0.29 | 36 / 1155 |
liver | 12% | 4.00 | 27 / 226 | 12% | 1.52 | 47 / 406 |
skin | 22% | 34.61 | 392 / 1809 | 0% | 0.00 | 1 / 472 |
thymus | 21% | 11.12 | 138 / 653 | 1% | 0.15 | 4 / 605 |
esophagus | 13% | 16.25 | 184 / 1445 | 8% | 0.92 | 15 / 183 |
breast | 19% | 14.96 | 88 / 459 | 1% | 0.12 | 7 / 1118 |
intestine | 12% | 4.53 | 115 / 966 | 6% | 0.74 | 34 / 527 |
stomach | 6% | 1.62 | 23 / 359 | 11% | 0.71 | 31 / 286 |
blood vessel | 17% | 25.94 | 225 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 15% | 11.50 | 141 / 929 | 0% | 0 | 0 / 0 |
uterus | 6% | 1.39 | 11 / 170 | 5% | 1.44 | 23 / 459 |
tonsil | 0% | 0 | 0 / 0 | 11% | 0.93 | 5 / 45 |
pancreas | 9% | 2.23 | 28 / 328 | 2% | 0.17 | 4 / 178 |
adrenal gland | 6% | 1.43 | 15 / 258 | 4% | 0.66 | 9 / 230 |
ovary | 7% | 1.67 | 13 / 180 | 0% | 0.01 | 1 / 430 |
spleen | 7% | 2.39 | 17 / 241 | 0% | 0 | 0 / 0 |
bladder | 5% | 0.71 | 1 / 21 | 2% | 0.37 | 11 / 504 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1902082 | Biological process | positive regulation of calcium ion import into sarcoplasmic reticulum |
GO_0031449 | Biological process | regulation of slow-twitch skeletal muscle fiber contraction |
GO_1901894 | Biological process | regulation of ATPase-coupled calcium transmembrane transporter activity |
GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
GO_0008047 | Molecular function | enzyme activator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | STRIT1 |
Protein name | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (SERCA regulator DWORF) (Dwarf open reading frame) (DWORF) (Small transmembrane regulator of ion transport 1) |
Synonyms | DWORF |
Description | FUNCTION: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). . |
Accessions | P0DN84 ENST00000489090.2 |