STRADB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032147Biological processactivation of protein kinase activity
GO_0007254Biological processJNK cascade
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0000902Biological processcell morphogenesis
GO_0006468Biological processprotein phosphorylation
GO_0006611Biological processprotein export from nucleus
GO_0005829Cellular componentcytosol
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0016235Cellular componentaggresome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameSTRADB
Protein nameSTE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)
STE20 related adaptor beta
SynonymsILPIP
ALS2CR2
PRO1038
DescriptionFUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). .

FUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. .

AccessionsENST00000194530.8 [Q9C0K7-1]
C9JSU7
ENST00000458269.6
ENST00000415688.1
ENST00000447698.5
F8WCQ7
H7C3S5
Q9C0K7
ENST00000392249.6 [Q9C0K7-2]