STRA8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of STRA8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STRA8 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0051321Biological processmeiotic cell cycle
GO_0007283Biological processspermatogenesis
GO_0048477Biological processoogenesis
GO_0006260Biological processDNA replication
GO_0090427Biological processactivation of meiosis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTRA8
Protein nameStimulated by retinoic acid 8
Stimulated by retinoic acid gene 8 protein homolog
Synonyms
DescriptionFUNCTION: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. .

AccessionsA0A590UK75
ENST00000667288.1
ENST00000662584.2
Q7Z7C7
A0A590UJF1
ENST00000275764.3