STEAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045055Biological processregulated exocytosis
GO_0015677Biological processcopper ion import
GO_0009725Biological processresponse to hormone
GO_0098705Biological processcopper ion import across plasma membrane
GO_0006897Biological processendocytosis
GO_0098711Biological processiron ion import across plasma membrane
GO_0006893Biological processGolgi to plasma membrane transport
GO_0010008Cellular componentendosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0008823Molecular functioncupric reductase (NADH) activity
GO_0052851Molecular functionferric-chelate reductase (NADPH) activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSTEAP2
Protein nameMetalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)
STEAP2 metalloreductase
Six transmembrane epithelial antigen of the prostate 2, isoform CRA_a (Six transmembrane prostate protein v1)
SynonymsSTAMP1
UNQ6507/PRO23203
PCANAP1
hCG_17233
DescriptionFUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). .

AccessionsB5MC02
ENST00000394622.6 [Q8NFT2-1]
Q8NFT2
C9JHX5
ENST00000394626.5 [Q8NFT2-2]
ENST00000394621.7 [Q8NFT2-1]
ENST00000428074.5
ENST00000394632.5 [Q8NFT2-3]
ENST00000394629.2 [Q8NFT2-2]
ENST00000287908.7 [Q8NFT2-1]
ENST00000402625.6
C9JLP2
ENST00000426158.1
Q6YPB2