I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| interneuron | 5 studies | 28% ± 6% | |
| neuron | 3 studies | 31% ± 8% | |
| GABAergic neuron | 3 studies | 26% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| interneuron | 5 studies | 28% ± 6% | |
| neuron | 3 studies | 31% ± 8% | |
| GABAergic neuron | 3 studies | 26% ± 6% |
Insufficient scRNA-seq data for expression of ST8SIA2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 85% | 107.98 | 2256 / 2642 | 58% | 3.25 | 406 / 705 |
| breast | 50% | 91.75 | 231 / 459 | 29% | 0.95 | 324 / 1118 |
| intestine | 67% | 23.82 | 652 / 966 | 4% | 0.15 | 22 / 527 |
| thymus | 41% | 12.27 | 269 / 653 | 30% | 1.02 | 184 / 605 |
| adrenal gland | 22% | 16.46 | 57 / 258 | 47% | 4.73 | 108 / 230 |
| heart | 66% | 135.77 | 567 / 861 | 0% | 0 | 0 / 0 |
| muscle | 63% | 55.26 | 508 / 803 | 0% | 0 | 0 / 0 |
| ovary | 10% | 3.00 | 18 / 180 | 53% | 2.73 | 229 / 430 |
| esophagus | 29% | 8.19 | 416 / 1445 | 20% | 0.61 | 36 / 183 |
| pancreas | 1% | 0.18 | 3 / 328 | 39% | 1.18 | 69 / 178 |
| uterus | 13% | 9.03 | 22 / 170 | 25% | 1.60 | 114 / 459 |
| skin | 14% | 3.99 | 262 / 1809 | 21% | 2.34 | 97 / 472 |
| stomach | 26% | 11.00 | 95 / 359 | 7% | 0.16 | 19 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 0.73 | 12 / 45 |
| adipose | 25% | 11.16 | 305 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 17% | 9.15 | 15 / 89 | 5% | 0.19 | 41 / 901 |
| lung | 4% | 0.93 | 23 / 578 | 16% | 0.70 | 190 / 1155 |
| prostate | 16% | 6.09 | 39 / 245 | 3% | 0.07 | 13 / 502 |
| eye | 0% | 0 | 0 / 0 | 14% | 0.36 | 11 / 80 |
| bladder | 5% | 1.10 | 1 / 21 | 8% | 0.35 | 40 / 504 |
| blood vessel | 8% | 2.58 | 102 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.05 | 4 / 406 |
| peripheral blood | 1% | 0.28 | 9 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0005975 | Biological process | carbohydrate metabolic process |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0097503 | Biological process | sialylation |
| GO_0042220 | Biological process | response to cocaine |
| GO_0001574 | Biological process | ganglioside biosynthetic process |
| GO_0036211 | Biological process | protein modification process |
| GO_0006491 | Biological process | N-glycan processing |
| GO_1990138 | Biological process | neuron projection extension |
| GO_0051965 | Biological process | positive regulation of synapse assembly |
| GO_0007399 | Biological process | nervous system development |
| GO_0009311 | Biological process | oligosaccharide metabolic process |
| GO_0006486 | Biological process | protein glycosylation |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0033691 | Molecular function | sialic acid binding |
| GO_0003828 | Molecular function | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity |
| GO_0000166 | Molecular function | nucleotide binding |
| Gene name | ST8SIA2 |
| Protein name | ST8SIA2 protein Alpha-2,8-sialyltransferase 8B 1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2) (cDNA, FLJ94563, Homo sapiens sialyltransferase 8B (alpha-2, 8-sialyltransferase)(SIAT8B), mRNA) Alpha-2,8-sialyltransferase 8B (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2) ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Alpha-2,8-sialyltransferase 8B (EC 2.4.3.-) (Sialyltransferase 8B) (SIAT8-B) (Sialyltransferase St8Sia II) (ST8SiaII) (Sialyltransferase X) (STX) |
| Synonyms | SIAT8B STX hCG_27594 |
| Description | FUNCTION: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable) . Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (Probable). However, does not exhibit sialic acid-polymerase activity (By similarity). Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth . ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons (By similarity). . |
| Accessions | Q92186 ENST00000539113.5 B2R9U8 G3V2T1 Q4VAZ2 C6G488 ENST00000268164.8 ENST00000555434.1 Q4VAY9 |
