Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 7 studies | 23% ± 8% | |
| smooth muscle cell | 6 studies | 24% ± 6% | |
| endothelial cell | 6 studies | 22% ± 6% | |
| pericyte | 5 studies | 20% ± 3% | |
| natural killer cell | 3 studies | 17% ± 2% | |
| glutamatergic neuron | 3 studies | 28% ± 6% |
Insufficient scRNA-seq data for expression of ST6GALNAC6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 4550.60 | 257 / 258 | 3% | 0.04 | 7 / 230 |
| lung | 100% | 9323.47 | 578 / 578 | 2% | 0.03 | 23 / 1155 |
| esophagus | 100% | 6922.77 | 1442 / 1445 | 2% | 0.03 | 4 / 183 |
| uterus | 100% | 7880.81 | 170 / 170 | 1% | 0.02 | 6 / 459 |
| ovary | 100% | 10780.11 | 180 / 180 | 1% | 0.01 | 4 / 430 |
| kidney | 100% | 5646.19 | 89 / 89 | 1% | 0.02 | 7 / 901 |
| intestine | 99% | 6769.94 | 959 / 966 | 1% | 0.02 | 6 / 527 |
| bladder | 100% | 7659.52 | 21 / 21 | 0% | 0.01 | 2 / 504 |
| breast | 100% | 9233.41 | 459 / 459 | 0% | 0.00 | 4 / 1118 |
| brain | 99% | 12227.28 | 2619 / 2642 | 1% | 0.02 | 7 / 705 |
| adipose | 100% | 12082.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 12216.97 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 8587.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| prostate | 100% | 5816.54 | 244 / 245 | 0% | 0.00 | 1 / 502 |
| thymus | 100% | 4755.05 | 650 / 653 | 0% | 0 | 0 / 605 |
| skin | 99% | 4743.59 | 1798 / 1809 | 0% | 0 | 0 / 472 |
| heart | 98% | 4540.18 | 848 / 861 | 0% | 0 | 0 / 0 |
| stomach | 96% | 4766.96 | 346 / 359 | 1% | 0.01 | 2 / 286 |
| pancreas | 97% | 3584.40 | 317 / 328 | 0% | 0 | 0 / 178 |
| liver | 96% | 3969.74 | 218 / 226 | 0% | 0 | 0 / 406 |
| muscle | 96% | 3278.65 | 774 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 65% | 2140.20 | 608 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 0.50 | 9 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006687 | Biological process | glycosphingolipid metabolic process |
| GO_0009312 | Biological process | oligosaccharide biosynthetic process |
| GO_0001574 | Biological process | ganglioside biosynthetic process |
| GO_0006688 | Biological process | glycosphingolipid biosynthetic process |
| GO_0009988 | Biological process | cell-cell recognition |
| GO_0009100 | Biological process | glycoprotein metabolic process |
| GO_0009311 | Biological process | oligosaccharide metabolic process |
| GO_0006677 | Biological process | glycosylceramide metabolic process |
| GO_0006486 | Biological process | protein glycosylation |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0001665 | Molecular function | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
| GO_0008373 | Molecular function | sialyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ST6GALNAC6 |
| Protein name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6-N-acetylgalactosaminide alpha-26-sialyltransferase 6 isoform 2) Epididymis secretory sperm binding protein (ST6-N-acetylgalactosaminide alpha-26-sialyltransferase 6 isoform 1) ST6 (Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, isoform CRA_d (cDNA FLJ57087, highly similar to Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, mRNA) ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F) |
| Synonyms | UNQ708/PRO1359 hCG_2039406 SIAT7F |
| Description | FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b . Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen . Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). . |
| Accessions | ENST00000373142.5 [Q969X2-3] ENST00000645007.1 ENST00000542456.5 ENST00000291839.10 ENST00000373144.7 [Q969X2-2] A0A0S2Z653 ENST00000373146.6 [Q969X2-1] Q969X2 F6SGE3 ENST00000622357.5 [Q969X2-2] A0A0S2Z5G9 B4DU80 ENST00000373141.5 [Q969X2-2] |
