Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 12 studies | 36% ± 12% | |
| goblet cell | 10 studies | 65% ± 19% | |
| club cell | 6 studies | 32% ± 7% | |
| respiratory goblet cell | 6 studies | 40% ± 16% | |
| basal cell | 5 studies | 37% ± 11% | |
| epithelial cell | 5 studies | 44% ± 17% | |
| secretory cell | 5 studies | 35% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 96% | 4550.88 | 345 / 359 | 90% | 72.61 | 258 / 286 |
| intestine | 89% | 6370.78 | 864 / 966 | 90% | 119.83 | 476 / 527 |
| prostate | 91% | 415.31 | 223 / 245 | 86% | 40.17 | 431 / 502 |
| lung | 87% | 541.82 | 500 / 578 | 72% | 47.08 | 827 / 1155 |
| esophagus | 80% | 1143.91 | 1153 / 1445 | 51% | 34.91 | 94 / 183 |
| uterus | 82% | 391.43 | 139 / 170 | 46% | 21.61 | 210 / 459 |
| ovary | 56% | 138.86 | 100 / 180 | 68% | 26.95 | 292 / 430 |
| spleen | 100% | 922.29 | 240 / 241 | 0% | 0 | 0 / 0 |
| bladder | 48% | 208.05 | 10 / 21 | 46% | 36.99 | 234 / 504 |
| pancreas | 14% | 32.63 | 47 / 328 | 79% | 57.77 | 141 / 178 |
| breast | 80% | 293.28 | 367 / 459 | 4% | 0.93 | 45 / 1118 |
| brain | 76% | 197.69 | 2012 / 2642 | 1% | 0.14 | 8 / 705 |
| heart | 71% | 202.80 | 611 / 861 | 0% | 0 | 0 / 0 |
| adipose | 70% | 226.85 | 848 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 58% | 23.15 | 26 / 45 |
| skin | 16% | 26.53 | 291 / 1809 | 4% | 1.39 | 18 / 472 |
| blood vessel | 19% | 39.79 | 248 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 13% | 22.62 | 87 / 653 | 0% | 0.07 | 2 / 605 |
| muscle | 9% | 13.04 | 76 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 6% | 10.82 | 57 / 929 | 0% | 0 | 0 / 0 |
| liver | 0% | 0.78 | 1 / 226 | 1% | 0.26 | 4 / 406 |
| adrenal gland | 0% | 1.45 | 1 / 258 | 0% | 0.42 | 1 / 230 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.11 | 3 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0009312 | Biological process | oligosaccharide biosynthetic process |
| GO_0048874 | Biological process | host-mediated regulation of intestinal microbiota composition |
| GO_0006486 | Biological process | protein glycosylation |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0001665 | Molecular function | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity |
| GO_0008373 | Molecular function | sialyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ST6GALNAC1 |
| Protein name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A) alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.3.3) |
| Synonyms | hCG_1640683 SIAT7A UNQ543/PRO848 |
| Description | FUNCTION: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis . Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins . Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers . Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation . . |
| Accessions | ENST00000359088.9 K7EMB6 Q8TBJ6 ENST00000589992.1 G3XAD9 ENST00000585633.1 ENST00000156626.12 K7EJC9 ENST00000592042.5 ENST00000589813.5 ENST00000590784.1 K7EJA8 Q9NSC7 K7ELU9 |
