ST3GAL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001574Biological processganglioside biosynthetic process
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0008373Molecular functionsialyltransferase activity
GO_0047291Molecular functionlactosylceramide alpha-2,3-sialyltransferase activity
GO_0003836Molecular functionbeta-galactoside (CMP) alpha-2,3-sialyltransferase activity

IV. Literature review

[source]
Gene nameST3GAL5
Protein nameLactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (GM3 synthase) (Ganglioside GM3 synthase) (ST3Gal V) (ST3GalV) (Sialyltransferase 9)
Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.3.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (Ganglioside GM3 synthase) (ST3Gal V) (Sialyltransferase 9)
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SynonymsUNQ2510/PRO5998
hCG_34610
SIAT9
DescriptionFUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) . Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) . .

AccessionsA0A1W2PR24
ENST00000638321.1
ENST00000639945.1
ENST00000638542.1
A0A1W2PRP8
ENST00000639305.1
ENST00000433665.6
ENST00000638484.1
ENST00000640425.1
A0A1W2PR45
Q9UNP4
ENST00000640222.1
ENST00000640378.1
ENST00000638678.1
ENST00000640903.1
ENST00000640849.1
ENST00000639119.1
A0A1W2PRY1
A0A1W2PQM6
ENST00000638288.1
A0A0S2Z4S6
ENST00000640024.1
A0A1W2PQ40
ENST00000639184.1
A0A1W2PRD9
ENST00000638885.1
ENST00000640992.1 [Q9UNP4-2]
ENST00000639311.1
ENST00000638572.2 [Q9UNP4-1]
A0A1W2PPG4
A0A1W2PR43
A0A1W2PNZ0
ENST00000639421.1
ENST00000639432.1 [Q9UNP4-2]
ENST00000640314.1
A0A1W2PPT1
ENST00000638178.1
A0A1W2PQH5
E7EPY0
ENST00000455892.1
A0A1W2PPQ6
A0A1W2PQB4
F8WEA8
ENST00000639820.1
ENST00000377332.8
ENST00000639981.1
ENST00000639541.1
A0A0S2Z4Q7
ENST00000306262.10
A0A1W2PRC6
ENST00000638258.1
A0A1W2PR69
ENST00000639608.1
A0A1W2PNV2
ENST00000638523.1
A0A1W2PP52
A0A1W2PQT6
ENST00000640763.1
A0A1W2PQR0
ENST00000639690.1
A0A1W2PQ22
C9JYS9
A0A1W2PQ01
ENST00000639519.1
A0A1W2PP82
ENST00000640835.1
ENST00000640572.1
A0A1W2PNR4
ENST00000640418.1
ENST00000640315.1
ENST00000638956.1
A0A1W2PP90
ENST00000639202.1
A0A1W2PRT0
A0A1W2PPB0
ENST00000640322.1 [Q9UNP4-2]
ENST00000638659.1
ENST00000638986.1 [Q9UNP4-2]
A0A1W2PQ08
ENST00000640594.1
ENST00000640295.1
ENST00000640982.1 [Q9UNP4-2]
A0A1W2PPF6
ENST00000638855.1
ENST00000393805.6 [Q9UNP4-2]
ENST00000393808.8 [Q9UNP4-3]
ENST00000638227.1
ENST00000473122.6
A0A1W2PQQ6
A0A1X7SBT2