ST3GAL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010706Biological processganglioside biosynthetic process via lactosylceramide
GO_0016266Biological processO-glycan processing
GO_0009312Biological processoligosaccharide biosynthetic process
GO_0009247Biological processglycolipid biosynthetic process
GO_0009101Biological processglycoprotein biosynthetic process
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0097503Biological processsialylation
GO_1990743Biological processprotein sialylation
GO_0019082Biological processviral protein processing
GO_0010707Biological processgloboside biosynthetic process via lactosylceramide
GO_0030259Biological processlipid glycosylation
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0008373Molecular functionsialyltransferase activity
GO_0047288Molecular functionbeta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase
GO_0003836Molecular functionbeta-galactoside (CMP) alpha-2,3-sialyltransferase activity

IV. Literature review

[source]
Gene nameST3GAL2
Protein nameCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (Alpha 2,3-ST 2) (Beta-galactoside alpha-2,3-sialyltransferase 2) (EC 2.4.3.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (Monosialoganglioside sialyltransferase) (EC 2.4.3.2) (ST3Gal II) (ST3GalII) (ST3GalA.2) (Sialyltransferase 4B) (SIAT4-B)
SynonymsSIAT4B
DescriptionFUNCTION: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids . Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage . Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively . Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 . Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser . .

AccessionsQ16842
ENST00000393640.8
ENST00000342907.3