SSTR2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SSTR2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	2391.54	2548 / 2642	94%	15.86	666 / 705
breast	95%	666.28	435 / 459	79%	9.09	880 / 1118
adrenal gland	93%	749.73	240 / 258	69%	15.92	158 / 230
kidney	99%	1196.43	88 / 89	61%	3.68	550 / 901
thymus	90%	473.54	588 / 653	42%	0.92	256 / 605
prostate	91%	586.47	224 / 245	26%	0.42	129 / 502
stomach	87%	341.52	313 / 359	25%	0.54	71 / 286
uterus	67%	282.26	114 / 170	33%	2.01	150 / 459
spleen	100%	2396.26	240 / 241	0%	0	0 / 0
adipose	98%	906.45	1176 / 1204	0%	0	0 / 0
pancreas	21%	52.74	70 / 328	64%	7.10	114 / 178
lymph node	0%	0	0 / 0	79%	6.55	23 / 29
liver	40%	103.61	90 / 226	37%	1.95	149 / 406
bladder	57%	185.29	12 / 21	18%	0.67	90 / 504
esophagus	42%	135.27	605 / 1445	31%	0.91	57 / 183
intestine	54%	160.45	520 / 966	15%	0.41	78 / 527
lung	30%	102.41	176 / 578	32%	1.47	370 / 1155
tonsil	0%	0	0 / 0	47%	3.22	21 / 45
blood vessel	41%	190.65	548 / 1335	0%	0	0 / 0
muscle	36%	105.20	292 / 803	0%	0	0 / 0
skin	16%	49.72	291 / 1809	20%	0.43	94 / 472
heart	33%	99.13	285 / 861	0%	0	0 / 0
ovary	13%	66.48	23 / 180	13%	0.31	58 / 430
peripheral blood	18%	225.01	171 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	10%	0.17	8 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0038170	Biological process	somatostatin signaling pathway
GO_0007218	Biological process	neuropeptide signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0030900	Biological process	forebrain development
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_0042594	Biological process	response to starvation
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0021549	Biological process	cerebellum development
GO_0071385	Biological process	cellular response to glucocorticoid stimulus
GO_0030432	Biological process	peristalsis
GO_0005886	Cellular component	plasma membrane
GO_0043005	Cellular component	neuron projection
GO_0005829	Cellular component	cytosol
GO_0004994	Molecular function	somatostatin receptor activity
GO_0030165	Molecular function	PDZ domain binding
GO_0042923	Molecular function	neuropeptide binding
GO_0005515	Molecular function	protein binding

Gene name	SSTR2
Protein name	Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)
Synonyms
Description	FUNCTION: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. .
Accessions	P30874 ENST00000357585.4 [P30874-1]

SSTR2 report