SRD5A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006489Biological processdolichyl diphosphate biosynthetic process
GO_0019408Biological processdolichol biosynthetic process
GO_0006702Biological processandrogen biosynthetic process
GO_0019348Biological processdolichol metabolic process
GO_0006488Biological processdolichol-linked oligosaccharide biosynthetic process
GO_0016095Biological processpolyprenol catabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0047751Molecular function3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity
GO_0016628Molecular functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO_0102389Molecular functionpolyprenol reductase activity
GO_0003865Molecular function3-oxo-5-alpha-steroid 4-dehydrogenase activity

IV. Literature review

[source]
Gene nameSRD5A3
Protein namePolyprenol reductase (EC 1.3.1.22) (EC 1.3.1.94)
Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 2-like) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)
Steroid 5 alpha-reductase 3
SynonymsSRD5A2L
DescriptionFUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol . Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation . Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism . Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) . .

FUNCTION: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). .; FUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. .

FUNCTION: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). .; FUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. .

AccessionsENST00000679836.1
H0Y9P9
ENST00000264228.9
A0A7I2V5I5
A0A7P0TBH6
ENST00000677177.2
ENST00000505210.1
Q9H8P0