SPRY3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPRY3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPRY3 at tissue level.

III. Associated gene sets

GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0048513Biological processanimal organ development
GO_0150013Biological processnegative regulation of neuron projection arborization
GO_0007399Biological processnervous system development
GO_0040037Biological processnegative regulation of fibroblast growth factor receptor signaling pathway
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSPRY3
Protein nameProtein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3)
Synonyms
DescriptionFUNCTION: Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation . May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis . .

AccessionsO43610
ENST00000675360.1
ENST00000302805.7
ENST00000695325.1