SPRR2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPRR2A at tissue level.

III. Associated gene sets

GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0048874Biological processhost-mediated regulation of intestinal microbiota composition
GO_0019731Biological processantibacterial humoral response
GO_0001533Cellular componentcornified envelope
GO_0030141Cellular componentsecretory granule
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0030133Cellular componenttransport vesicle
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene nameSPRR2A
Protein nameSmall proline-rich protein 2A (SPR-2A) (2-1)
Synonyms
DescriptionFUNCTION: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption . Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids . Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo . .

AccessionsP35326
ENST00000392653.3