I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| squamous epithelial cell | 4 studies | 46% ± 13% | |
| keratinocyte | 4 studies | 20% ± 3% | |
| epithelial cell | 3 studies | 48% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| squamous epithelial cell | 4 studies | 46% ± 13% | |
| keratinocyte | 4 studies | 20% ± 3% | |
| epithelial cell | 3 studies | 48% ± 15% |
Insufficient scRNA-seq data for expression of SPRR1B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 41% | 18475.45 | 591 / 1445 | 60% | 3599.72 | 109 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 1881.48 | 40 / 45 |
| skin | 71% | 7287.03 | 1293 / 1809 | 11% | 266.14 | 50 / 472 |
| uterus | 1% | 1224.74 | 2 / 170 | 45% | 1044.21 | 205 / 459 |
| lung | 0% | 0 | 0 / 578 | 32% | 419.60 | 367 / 1155 |
| bladder | 0% | 0 | 0 / 21 | 19% | 267.93 | 98 / 504 |
| pancreas | 0% | 3.63 | 1 / 328 | 16% | 48.98 | 28 / 178 |
| intestine | 0% | 0 | 0 / 966 | 6% | 167.53 | 34 / 527 |
| stomach | 1% | 19.58 | 3 / 359 | 3% | 33.29 | 8 / 286 |
| adrenal gland | 0% | 0 | 0 / 258 | 2% | 13.44 | 4 / 230 |
| breast | 0% | 4.70 | 1 / 459 | 2% | 7.80 | 17 / 1118 |
| ovary | 0% | 0 | 0 / 180 | 2% | 3.74 | 7 / 430 |
| thymus | 0% | 4.96 | 1 / 653 | 1% | 1.64 | 4 / 605 |
| adipose | 0% | 9.15 | 6 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 0% | 13.69 | 2 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 5.31 | 3 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 9.49 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| brain | 0% | 0 | 0 / 2642 | 0% | 0 | 0 / 705 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0 | 0 / 901 |
| liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0 | 0 / 502 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030216 | Biological process | keratinocyte differentiation |
| GO_0031424 | Biological process | keratinization |
| GO_0008544 | Biological process | epidermis development |
| GO_0018149 | Biological process | peptide cross-linking |
| GO_0001533 | Cellular component | cornified envelope |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005198 | Molecular function | structural molecule activity |
| Gene name | SPRR1B |
| Protein name | Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB) |
| Synonyms | |
| Description | FUNCTION: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage. |
| Accessions | ENST00000307098.5 P22528 |
