SPR report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPR at tissue level.

III. Associated gene sets

GO_0006809Biological processnitric oxide biosynthetic process
GO_0006729Biological processtetrahydrobiopterin biosynthetic process
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0050661Molecular functionNADP binding
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0004757Molecular functionsepiapterin reductase (NADP+) activity

IV. Literature review

[source]
Gene nameSPR
Protein nameSepiapterin reductase (SPR) (EC 1.1.1.153)
Sepiapterin Reductase (EC 1.1.1.153)
Synonyms
DescriptionFUNCTION: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

AccessionsP35270
Q9UEC5
ENST00000234454.6