Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 6 studies | 26% ± 8% | |
| ciliated cell | 4 studies | 21% ± 4% | |
| intestinal crypt stem cell | 3 studies | 16% ± 0% |
Insufficient scRNA-seq data for expression of SPR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 2288.88 | 328 / 328 | 100% | 93.89 | 178 / 178 |
| prostate | 100% | 1831.52 | 245 / 245 | 100% | 142.04 | 501 / 502 |
| kidney | 100% | 2521.70 | 89 / 89 | 100% | 113.06 | 899 / 901 |
| liver | 100% | 3421.53 | 226 / 226 | 100% | 146.89 | 405 / 406 |
| stomach | 100% | 2096.32 | 359 / 359 | 99% | 112.53 | 283 / 286 |
| intestine | 100% | 1951.88 | 965 / 966 | 99% | 138.03 | 522 / 527 |
| breast | 100% | 1378.13 | 459 / 459 | 99% | 134.77 | 1104 / 1118 |
| uterus | 99% | 998.16 | 169 / 170 | 98% | 77.42 | 451 / 459 |
| adrenal gland | 100% | 3247.33 | 258 / 258 | 97% | 85.34 | 224 / 230 |
| bladder | 100% | 1706.05 | 21 / 21 | 97% | 98.40 | 490 / 504 |
| lung | 98% | 1126.41 | 566 / 578 | 99% | 97.56 | 1144 / 1155 |
| esophagus | 100% | 1438.00 | 1443 / 1445 | 97% | 64.75 | 177 / 183 |
| skin | 96% | 731.00 | 1737 / 1809 | 99% | 94.26 | 468 / 472 |
| ovary | 99% | 751.99 | 178 / 180 | 96% | 62.82 | 414 / 430 |
| thymus | 100% | 1477.38 | 652 / 653 | 94% | 52.58 | 568 / 605 |
| brain | 79% | 552.17 | 2091 / 2642 | 93% | 39.27 | 655 / 705 |
| eye | 0% | 0 | 0 / 0 | 100% | 122.20 | 80 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 53.75 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 41.90 | 1 / 1 |
| adipose | 100% | 1429.00 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1662.02 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1173.99 | 1323 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1675.74 | 851 / 861 | 0% | 0 | 0 / 0 |
| spleen | 98% | 632.18 | 235 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 12.98 | 15 / 29 |
| peripheral blood | 21% | 109.12 | 198 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006809 | Biological process | nitric oxide biosynthetic process |
| GO_0006729 | Biological process | tetrahydrobiopterin biosynthetic process |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0050661 | Molecular function | NADP binding |
| GO_0004033 | Molecular function | aldo-keto reductase (NADPH) activity |
| GO_0004757 | Molecular function | sepiapterin reductase (NADP+) activity |
| Gene name | SPR |
| Protein name | Sepiapterin reductase (SPR) (EC 1.1.1.153) Sepiapterin Reductase (EC 1.1.1.153) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| Accessions | P35270 Q9UEC5 ENST00000234454.6 |