SPOPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0030162Biological processregulation of proteolysis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPOPL
Protein nameSpeckle type BTB/POZ protein like
Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2)
Synonyms
DescriptionFUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. .

AccessionsENST00000430968.5
F8WD02
ENST00000280098.9
ENST00000420679.1
Q6IQ16
F8WBB7