SPNS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048535Biological processlymph node development
GO_0043029Biological processT cell homeostasis
GO_0030148Biological processsphingolipid biosynthetic process
GO_0007605Biological processsensory perception of sound
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0072676Biological processlymphocyte migration
GO_0060348Biological processbone development
GO_0002920Biological processregulation of humoral immune response
GO_0001782Biological processB cell homeostasis
GO_2000404Biological processregulation of T cell migration
GO_0048073Biological processregulation of eye pigmentation
GO_0055085Biological processtransmembrane transport
GO_0006869Biological processlipid transport
GO_0010008Cellular componentendosome membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0046624Molecular functionsphingolipid transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSPNS2
Protein nameSphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2)
SPNS lysolipid transporter 2, sphingosine-1-phosphate
Synonyms
DescriptionFUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking . S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system . Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking . Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function . S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity). .

AccessionsENST00000329078.8
I3L4N9
Q8IVW8
ENST00000571386.1