SPDL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPDL1 at tissue level.

III. Associated gene sets

GO_0034501Biological processprotein localization to kinetochore
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0016477Biological processcell migration
GO_0005813Cellular componentcentrosome
GO_0000940Cellular componentouter kinetochore
GO_0005829Cellular componentcytosol
GO_0000922Cellular componentspindle pole
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding
GO_0043515Molecular functionkinetochore binding

IV. Literature review

[source]
Gene nameSPDL1
Protein nameSpindle apparatus coiled-coil protein 1
Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)
SynonymsCCDC99
DescriptionFUNCTION: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment . Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) . Plays a role in cell migration . .

AccessionsENST00000265295.9 [Q96EA4-1]
H7C5V2
ENST00000513941.5
ENST00000515224.5
ENST00000503871.1
Q96EA4
ENST00000507232.5
ENST00000512028.5
D6RDK5
ENST00000508247.5
D6RIB8
ENST00000505977.1
D6REZ1
ENST00000629457.2
D6RIF7
ENST00000506574.5
ENST00000509785.5
H0YBG5
D6RC83
D6R936
D6RCL1
ENST00000513795.1