I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 23% ± 4% | |
| Mueller cell | 3 studies | 21% ± 6% | |
| transit amplifying cell | 3 studies | 22% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 23% ± 4% | |
| Mueller cell | 3 studies | 21% ± 6% | |
| transit amplifying cell | 3 studies | 22% ± 6% |
Insufficient scRNA-seq data for expression of SPC25 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 88% | 260.38 | 1590 / 1809 | 91% | 13.76 | 428 / 472 |
| stomach | 74% | 88.19 | 264 / 359 | 97% | 19.55 | 278 / 286 |
| lung | 84% | 75.80 | 486 / 578 | 85% | 14.11 | 979 / 1155 |
| pancreas | 80% | 45.76 | 262 / 328 | 89% | 9.86 | 158 / 178 |
| breast | 73% | 43.49 | 336 / 459 | 94% | 15.27 | 1046 / 1118 |
| ovary | 67% | 34.84 | 120 / 180 | 97% | 20.87 | 416 / 430 |
| intestine | 61% | 90.59 | 588 / 966 | 97% | 20.77 | 513 / 527 |
| esophagus | 54% | 98.47 | 780 / 1445 | 97% | 16.36 | 178 / 183 |
| bladder | 48% | 18.33 | 10 / 21 | 93% | 17.54 | 467 / 504 |
| uterus | 42% | 19.59 | 72 / 170 | 98% | 24.08 | 449 / 459 |
| brain | 59% | 23.31 | 1557 / 2642 | 72% | 12.29 | 506 / 705 |
| adrenal gland | 83% | 54.68 | 214 / 258 | 35% | 3.89 | 80 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 30.05 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 25.04 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.89 | 1 / 1 |
| spleen | 98% | 137.37 | 235 / 241 | 0% | 0 | 0 / 0 |
| kidney | 66% | 55.38 | 59 / 89 | 28% | 1.95 | 251 / 901 |
| liver | 29% | 28.64 | 66 / 226 | 51% | 4.89 | 209 / 406 |
| prostate | 56% | 27.71 | 136 / 245 | 19% | 1.42 | 93 / 502 |
| adipose | 63% | 35.24 | 762 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 47% | 18.92 | 306 / 653 | 16% | 5.09 | 95 / 605 |
| peripheral blood | 58% | 298.79 | 536 / 929 | 0% | 0 | 0 / 0 |
| heart | 32% | 11.86 | 272 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 20% | 7.84 | 265 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 18% | 1.09 | 14 / 80 |
| muscle | 9% | 2.34 | 71 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008608 | Biological process | attachment of spindle microtubules to kinetochore |
| GO_0051301 | Biological process | cell division |
| GO_0007094 | Biological process | mitotic spindle assembly checkpoint signaling |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0007052 | Biological process | mitotic spindle organization |
| GO_0031262 | Cellular component | Ndc80 complex |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SPC25 |
| Protein name | Kinetochore protein Spc25 (hSpc25) Kinetochore protein Spc25 (SPC25 component of NDC80 kinetochore complex) |
| Synonyms | AD024 SPBC25 |
| Description | FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules . . |
| Accessions | ENST00000611144.4 ENST00000282074.7 Q9HBM1 ENST00000451987.5 C9JW94 ENST00000616584.1 ENST00000612416.4 |
