SPC24 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPC24 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPC24 at tissue level.

III. Associated gene sets

GO_0008608Biological processattachment of spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0007059Biological processchromosome segregation
GO_0031262Cellular componentNdc80 complex
GO_0000776Cellular componentkinetochore
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameSPC24
Protein nameSPC24 component of NDC80 kinetochore complex
Kinetochore protein Spc24
Kinetochore protein Spc24 (hSpc24)
SynonymsSPBC24
DescriptionFUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules . .

FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. .

FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. .

AccessionsA0A0A0MSN0
ENST00000586708.1
ENST00000591396.5
K7ERQ7
K7ESQ2
K7EMX1
ENST00000585486.1
K7EJH0
Q8NBT2
ENST00000592540.6 [Q8NBT2-1]
ENST00000592967.5
K7EJV2
ENST00000423327.2
ENST00000585567.5