SPAG17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904158Biological processaxonemal central apparatus assembly
GO_1990953Biological processintramanchette transport
GO_1905198Biological processmanchette assembly
GO_0007283Biological processspermatogenesis
GO_0003351Biological processepithelial cilium movement involved in extracellular fluid movement
GO_0044458Biological processmotile cilium assembly
GO_1990716Cellular componentaxonemal central apparatus
GO_0031514Cellular componentmotile cilium
GO_0001669Cellular componentacrosomal vesicle
GO_0002177Cellular componentmanchette
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0005874Cellular componentmicrotubule

IV. Literature review

[source]
Gene nameSPAG17
Protein nameSperm-associated antigen 17 (Projection protein PF6 homolog)
Sperm associated antigen 17
Synonyms
DescriptionFUNCTION: Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts (By similarity). Essential for normal spermatogenesis and male fertility (By similarity). Required for normal manchette structure, transport of proteins along the manchette microtubules and formation of the sperm head and flagellum (By similarity). Essential for sperm flagellum development and proper assembly of the respiratory motile cilia central pair apparatus, but not the brain ependymal cilia (By similarity). .

AccessionsQ5TDG6
ENST00000437255.1
E0ZS55
A7LBF9
Q6Q759
ENST00000336338.10