SOCS7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0035556Biological processintracellular signal transduction
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0008150Biological processbiological_process
GO_0009968Biological processnegative regulation of signal transduction
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSOCS7
Protein nameSuppressor of cytokine signaling 7
Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Suppressor of cytokine-signaling 7
SynonymsNAP4
SOCS6
DescriptionFUNCTION: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). .

AccessionsENST00000617765.1
A0A0J9YXY1
A0A087WZ14
ENST00000615473.2 [O14512-1]
ENST00000612932.6
A0A5F9YLF9
O14512
A0A087X1Q5
ENST00000632687.1
ENST00000631692.1
ENST00000613678.5
ENST00000665913.1 [O14512-1]