SOCS6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006952Biological processdefense response
GO_0016567Biological processprotein ubiquitination
GO_0050868Biological processnegative regulation of T cell activation
GO_0035556Biological processintracellular signal transduction
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0040008Biological processregulation of growth
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0009968Biological processnegative regulation of signal transduction
GO_0010498Biological processproteasomal protein catabolic process
GO_0001772Cellular componentimmunological synapse
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity

IV. Literature review

[source]
Gene nameSOCS6
Protein nameSuppressor of cytokine signaling 6
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
SynonymsCIS4
SOCS4
DescriptionFUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. .

AccessionsJ3KTM7
ENST00000582322.1
ENST00000397942.4
ENST00000578377.1
O14544