SNX18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0016197Biological processendosomal transport
GO_0036089Biological processcleavage furrow formation
GO_0000281Biological processmitotic cytokinesis
GO_0006897Biological processendocytosis
GO_0097320Biological processplasma membrane tubulation
GO_0043547Biological processpositive regulation of GTPase activity
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0035091Molecular functionphosphatidylinositol binding

IV. Literature review

[source]
Gene nameSNX18
Protein nameSorting nexin-18 (SH3 and PX domain-containing protein 3B)
SynonymsSH3PXD3B
DescriptionFUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis . Required for efficient progress through mitosis and cytokinesis . Required for normal formation of the cleavage furrow at the end of mitosis . Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis . Plays a role in macropinocytosis . Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation . Stimulates the GTPase activity of DNM2 . Promotes DNM2 location at the plasma membrane . Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A . .

AccessionsQ96RF0
ENST00000343017.11 [Q96RF0-1]
ENST00000381410.5 [Q96RF0-2]
ENST00000326277.5 [Q96RF0-3]