SMPDL3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006685Biological processsphingomyelin catabolic process
GO_0009143Biological processnucleoside triphosphate catabolic process
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0004767Molecular functionsphingomyelin phosphodiesterase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0008081Molecular functionphosphoric diester hydrolase activity

IV. Literature review

[source]
Gene nameSMPDL3A
Protein nameCyclic GMP-AMP phosphodiesterase SMPDL3A (2',3'-cGAMP phosphodiesterase SMPDL3A) (EC 3.1.4.-) (Acid sphingomyelinase-like phosphodiesterase 3a) (ASM-like phosphodiesterase 3a) (EC 3.6.1.15)
SynonymsASML3A
DescriptionFUNCTION: Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling . Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA . Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP . Has in vitro activity with p-nitrophenyl-TMP . Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates . Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine . Does not have sphingomyelin phosphodiesterase activity . .

AccessionsQ92484
ENST00000539041.5 [Q92484-2]
ENST00000368440.5 [Q92484-1]