SMPD4 | OmnibusX

Name	Number of supported studies	Average coverage
liver	3 studies	22% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3919.26	1445 / 1445	100%	50.84	183 / 183
skin	100%	4559.22	1809 / 1809	100%	36.23	472 / 472
stomach	100%	3060.79	359 / 359	100%	37.28	286 / 286
prostate	100%	4846.37	245 / 245	100%	29.54	501 / 502
ovary	100%	4991.29	180 / 180	100%	43.42	429 / 430
intestine	100%	3945.27	966 / 966	100%	36.02	525 / 527
bladder	100%	3970.52	21 / 21	100%	33.13	502 / 504
lung	100%	3444.88	578 / 578	100%	35.54	1150 / 1155
breast	100%	4118.16	459 / 459	99%	39.51	1112 / 1118
pancreas	100%	2306.26	328 / 328	99%	26.50	177 / 178
uterus	100%	5639.21	170 / 170	99%	40.31	456 / 459
thymus	100%	6203.04	653 / 653	99%	28.16	600 / 605
brain	99%	3024.81	2618 / 2642	100%	25.29	703 / 705
adrenal gland	100%	3540.72	258 / 258	99%	29.89	227 / 230
kidney	100%	3280.44	89 / 89	97%	20.83	873 / 901
liver	100%	2320.63	226 / 226	93%	16.84	376 / 406
adipose	100%	3472.11	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	24.96	80 / 80
lymph node	0%	0	0 / 0	100%	30.74	29 / 29
spleen	100%	3897.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.65	45 / 45
ureter	0%	0	0 / 0	100%	21.85	1 / 1
blood vessel	100%	3972.02	1334 / 1335	0%	0	0 / 0
muscle	100%	2256.48	801 / 803	0%	0	0 / 0
heart	99%	2453.89	852 / 861	0%	0	0 / 0
peripheral blood	80%	2101.79	742 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007029	Biological process	endoplasmic reticulum organization
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0006685	Biological process	sphingomyelin catabolic process
GO_0046475	Biological process	glycerophospholipid catabolic process
GO_0046513	Biological process	ceramide biosynthetic process
GO_0005802	Cellular component	trans-Golgi network
GO_0005635	Cellular component	nuclear envelope
GO_0000139	Cellular component	Golgi membrane
GO_0042383	Cellular component	sarcolemma
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0005640	Cellular component	nuclear outer membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0050290	Molecular function	sphingomyelin phosphodiesterase D activity
GO_0004767	Molecular function	sphingomyelin phosphodiesterase activity
GO_0046872	Molecular function	metal ion binding

Gene name	SMPD4
Protein name	Sphingomyelin phosphodiesterase 4 Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) Alternative protein SMPD4
Synonyms	KIAA1418 SKNY
Description	FUNCTION: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide . It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function . May sensitize cells to DNA damage-induced apoptosis . In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). .
Accessions	ENST00000449159.5 ENST00000433118.5 ENST00000351288.10 [Q9NXE4-2] ENST00000680810.1 ENST00000435455.6 ENST00000412570.5 A0A7P0Z453 A0A7P0TB44 F2Z2W5 F2Z2I0 H7C235 ENST00000451542.5 H7C1Q6 H7C2E2 ENST00000441135.1 ENST00000431183.6 [Q9NXE4-6] H7C2J2 A0A7P0TB24 L8ECH3 ENST00000680987.1 ENST00000680196.1 F8WF03 A0A7P0T8J0 A0A7P0T9J6 ENST00000454468.5 ENST00000680679.1 A0A7P0TAZ0 H7C0W5 ENST00000709800.1 [Q9NXE4-6] ENST00000439886.5 ENST00000709804.1 [Q9NXE4-2] ENST00000709809.1 [Q9NXE4-1] C9J647 ENST00000439029.5 ENST00000457039.6 F8WEQ5 ENST00000430682.5 ENST00000680401.1 Q9NXE4 ENST00000680298.1 ENST00000409031.5 [Q9NXE4-1]

SMPD4 report