SMG8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SMG8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMG8 at tissue level.

III. Associated gene sets

GO_0045859Biological processregulation of protein kinase activity
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0005575Cellular componentcellular_component
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMG8
Protein nameNonsense-mediated mRNA decay factor SMG8
Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)
SynonymsABC2
C17orf71
DescriptionFUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. .

FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. .

FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. .

AccessionsENST00000580798.1
ENST00000578922.1 [Q8ND04-3]
ENST00000300917.10 [Q8ND04-1]
Q8ND04
J3KTD7
ENST00000543872.6 [Q8ND04-1]
J3QKP6
ENST00000582469.1