SMG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0032210Biological processregulation of telomere maintenance via telomerase
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0035303Biological processregulation of dephosphorylation
GO_0032204Biological processregulation of telomere maintenance
GO_0005829Cellular componentcytosol
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070034Molecular functiontelomerase RNA binding
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSMG5
Protein nameNonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)
SynonymsKIAA1089
EST1B
DescriptionFUNCTION: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. .

AccessionsQ9UPR3
ENST00000361813.5