SMC1B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SMC1B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMC1B at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0007062Biological processsister chromatid cohesion
GO_0030893Cellular componentmeiotic cohesin complex
GO_0000775Cellular componentchromosome, centromeric region
GO_0000800Cellular componentlateral element
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameSMC1B
Protein nameStructural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B)
SynonymsSMC1L2
DescriptionFUNCTION: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). .

AccessionsENST00000404354.3 [Q8NDV3-2]
Q8NDV3
ENST00000357450.9 [Q8NDV3-3]