SLFN12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLFN12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLFN12 at tissue level.

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0016075Biological processrRNA catabolic process
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0005515Molecular functionprotein binding
GO_0004540Molecular functionRNA nuclease activity

IV. Literature review

[source]
Gene nameSLFN12
Protein nameRibonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12)
Schlafen family member 12
Synonyms
DescriptionFUNCTION: Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling . May play a role in cell differentiation . .

AccessionsENST00000452764.3
Q8IYM2
ENST00000447040.6
ENST00000445092.5
ENST00000304905.10
ENST00000394562.5
C9JIA1
C9J4K7