Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 30% ± 9% | |
| endothelial cell of artery | 7 studies | 29% ± 9% | |
| vein endothelial cell | 7 studies | 23% ± 9% | |
| endothelial cell of vascular tree | 7 studies | 24% ± 9% | |
| capillary endothelial cell | 6 studies | 36% ± 10% | |
| squamous epithelial cell | 3 studies | 28% ± 4% | |
| extravillous trophoblast | 3 studies | 37% ± 8% |
Insufficient scRNA-seq data for expression of SLCO4A1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 94% | 1515.40 | 337 / 359 | 96% | 48.56 | 275 / 286 |
| intestine | 89% | 1460.58 | 862 / 966 | 98% | 52.49 | 514 / 527 |
| esophagus | 95% | 2222.76 | 1378 / 1445 | 85% | 25.67 | 156 / 183 |
| kidney | 87% | 3988.13 | 77 / 89 | 80% | 21.86 | 721 / 901 |
| lung | 99% | 8946.21 | 573 / 578 | 59% | 9.87 | 677 / 1155 |
| uterus | 89% | 2123.09 | 152 / 170 | 63% | 13.29 | 288 / 459 |
| bladder | 90% | 2156.33 | 19 / 21 | 52% | 19.29 | 262 / 504 |
| skin | 72% | 2941.35 | 1302 / 1809 | 70% | 16.25 | 331 / 472 |
| brain | 74% | 1576.79 | 1958 / 2642 | 59% | 4.94 | 415 / 705 |
| breast | 98% | 4378.96 | 451 / 459 | 20% | 1.72 | 220 / 1118 |
| thymus | 80% | 1478.96 | 521 / 653 | 37% | 2.95 | 224 / 605 |
| pancreas | 16% | 123.31 | 51 / 328 | 83% | 21.91 | 148 / 178 |
| adipose | 98% | 5068.16 | 1184 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 19.82 | 76 / 80 |
| muscle | 88% | 1848.79 | 706 / 803 | 0% | 0 | 0 / 0 |
| heart | 83% | 2126.85 | 713 / 861 | 0% | 0 | 0 / 0 |
| ovary | 52% | 1147.32 | 93 / 180 | 25% | 2.16 | 108 / 430 |
| prostate | 66% | 916.64 | 162 / 245 | 8% | 0.47 | 39 / 502 |
| spleen | 73% | 792.87 | 176 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 11.73 | 21 / 29 |
| blood vessel | 67% | 1124.11 | 890 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 36% | 516.36 | 92 / 258 | 30% | 5.15 | 69 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 62% | 9.45 | 28 / 45 |
| peripheral blood | 41% | 654.45 | 382 / 929 | 0% | 0 | 0 / 0 |
| liver | 20% | 218.67 | 46 / 226 | 11% | 1.53 | 43 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0015732 | Biological process | prostaglandin transport |
| GO_0070327 | Biological process | thyroid hormone transport |
| GO_0043252 | Biological process | sodium-independent organic anion transport |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0015132 | Molecular function | prostaglandin transmembrane transporter activity |
| GO_0015349 | Molecular function | thyroid hormone transmembrane transporter activity |
| GO_0008514 | Molecular function | organic anion transmembrane transporter activity |
| GO_0015347 | Molecular function | sodium-independent organic anion transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLCO4A1 |
| Protein name | Solute carrier organic anion transporter family member 4A1 Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) |
| Synonyms | OATPE SLC21A12 OATP4A1 OATP1 hCG_1748044 |
| Description | FUNCTION: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner . May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta . The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). . |
| Accessions | ENST00000497209.5 E1P5H9 ENST00000451793.1 ENST00000370507.5 [Q96BD0-1] A0A0A0MT51 ENST00000217159.6 [Q96BD0-1] Q96BD0 |
