SLC9B2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055078Biological processsodium ion homeostasis
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0010351Biological processlithium ion transport
GO_0098662Biological processinorganic cation transmembrane transport
GO_0030317Biological processflagellated sperm motility
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0006814Biological processsodium ion transport
GO_0072583Biological processclathrin-dependent endocytosis
GO_2001206Biological processpositive regulation of osteoclast development
GO_0035725Biological processsodium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0031966Cellular componentmitochondrial membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0097228Cellular componentsperm principal piece
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0042802Molecular functionidentical protein binding
GO_0010348Molecular functionlithium:proton antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC9B2
Protein nameSolute carrier family 9 member B2 (cDNA FLJ50743)
Sodium/hydrogen exchanger 9B2 (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)
Solute carrier family 9 member B2
Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.104) (EC 1.1.1.30) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (4-oxo-L-proline reductase) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)
SynonymsNHEDC2
NHA2
DescriptionFUNCTION: Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane . Uses the proton gradient/membrane potential to extrude sodium . Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney . May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). .

AccessionsENST00000508136.1
ENST00000503818.1
ENST00000503230.5
ENST00000362026.7 [Q86UD5-1]
ENST00000394785.9 [Q86UD5-1]
Q86UD5
B7Z676
A0A0C4DGB3
D6R9P2
ENST00000503103.5
ENST00000506288.5
E9PE63
D6RGJ7