SLC9A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0097484Biological processdendrite extension
GO_0006811Biological processmonoatomic ion transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_0048812Biological processneuron projection morphogenesis
GO_0098719Biological processsodium ion import across plasma membrane
GO_0048675Biological processaxon extension
GO_0051453Biological processregulation of intracellular pH
GO_1902600Biological processproton transmembrane transport
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC9A6
Protein nameSodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)
Sodium/hydrogen exchanger
Solute carrier family 9 member A6
SynonymsNHE6
KIAA0267
DescriptionFUNCTION: Endosomal Na(+), K(+)/H(+) antiporter . Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo . Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH . Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity). .

AccessionsENST00000674809.1
A0A6Q8PGY5
A0A1B0GV11
ENST00000637195.1
ENST00000370698.7 [Q92581-1]
ENST00000630721.3
ENST00000676043.1
A0A0D9SFM4
ENST00000636092.1 [Q92581-3]
ENST00000370701.6 [Q92581-3]
A0A1B0GTT2
ENST00000637234.1 [Q92581-3]
ENST00000678163.1
ENST00000637581.1 [Q92581-3]
ENST00000627534.2
A0A6Q8PFS7
Q92581
A0A7I2V2B0
ENST00000638078.1
A0A0D9SGH0
ENST00000636347.1 [Q92581-3]
ENST00000370695.8 [Q92581-2]