SLC9A4 | OmnibusX

Name	Number of supported studies	Average coverage
renal principal cell	4 studies	23% ± 0%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC9A4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	374.89	89 / 89	12%	1.13	104 / 901
stomach	82%	2396.04	294 / 359	28%	3.03	81 / 286
ureter	0%	0	0 / 0	100%	6.09	1 / 1
bladder	48%	42.24	10 / 21	38%	4.72	189 / 504
ovary	11%	4.09	19 / 180	70%	3.45	300 / 430
esophagus	34%	69.48	495 / 1445	33%	2.94	60 / 183
skin	59%	23.90	1074 / 1809	1%	0.02	3 / 472
pancreas	4%	1.83	13 / 328	45%	3.36	80 / 178
lung	2%	0.60	9 / 578	21%	1.78	247 / 1155
intestine	6%	3.20	56 / 966	14%	1.57	74 / 527
peripheral blood	18%	3.79	166 / 929	0%	0	0 / 0
uterus	5%	1.60	8 / 170	12%	1.06	55 / 459
tonsil	0%	0	0 / 0	13%	0.61	6 / 45
prostate	7%	2.01	18 / 245	0%	0.00	1 / 502
spleen	5%	0.68	11 / 241	0%	0	0 / 0
breast	2%	0.62	10 / 459	1%	0.03	16 / 1118
brain	2%	0.53	58 / 2642	0%	0.01	3 / 705
thymus	1%	0.20	5 / 653	1%	0.06	7 / 605
adipose	2%	0.65	19 / 1204	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.05	6 / 406
blood vessel	0%	0.10	6 / 1335	0%	0	0 / 0
adrenal gland	0%	0.92	1 / 258	0%	0	0 / 230
muscle	0%	0.05	3 / 803	0%	0	0 / 0
heart	0%	0.15	2 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0098719	Biological process	sodium ion import across plasma membrane
GO_0006811	Biological process	monoatomic ion transport
GO_0051453	Biological process	regulation of intracellular pH
GO_0001696	Biological process	gastric acid secretion
GO_0002068	Biological process	glandular epithelial cell development
GO_0070634	Biological process	transepithelial ammonium transport
GO_0071805	Biological process	potassium ion transmembrane transport
GO_1902600	Biological process	proton transmembrane transport
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0042589	Cellular component	zymogen granule membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015385	Molecular function	sodium:proton antiporter activity
GO_0015386	Molecular function	potassium:proton antiporter activity

Gene name	SLC9A4
Protein name	Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)
Synonyms	NHE4
Description	FUNCTION: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). .
Accessions	Q6AI14 ENST00000295269.5

SLC9A4 report